Bulk TCR-seq showed a trend toward reduced overall clonotype diversity and increased expansion of large and hyperexpanded clones following SMG1i, alone or in combination with αPD-1, with a corresponding reduction in small and medium clones, further suggesting that the elevated T cell response is antigen dependent ( Figures 3D, 3E , and S4H–S4J ).
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Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome.
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