Vaccination against helminth IL-33 modulators permits immune-mediated parasite ejection.

By each of these measures, HpARI1 had a similar but smaller effect than HpARI2, and trends for increases with HpARI1 did not reach statistical significance in these experiments.

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This was associated with increased ILC2 responses, as seen previously with HpARI2 vaccination at day 7 of infection ( Figure 2H ), and although this did not reach significance in this experiment at day 7, at day 14 of infection, a highly significant expansion of ILC2s was evident ( Figure 6B ).

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