Barely Significant
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Human MASLD is a diurnal disease driven by multisystem insulin resistance and reduced insulin availability at night.

Cell Metab · 2026 · PMC7619395 · PMID 41529695

Europe PMCDOI
3
hedged sentences
0.0570
closest p · 1.1× alpha
0.0580
boldest claim

The sentences

borderline significantp = 0.057so close (0.05 < p ≤ 0.1)
In controls, two adipose proteins (EMD and INF2) were significantly downregulated at night compared with day, while PPOX, UPE2M, and APOE were borderline significant after adjustment for multiple comparisons (adjusted p = 0.057, 0.069, and 0.061, respectively).

also in 11,409 other papers

borderline significancep = 0.058so close (0.05 < p ≤ 0.1)
Plasminogen-activator inhibitor-1 (PAI-1; SERPINE1) was also downregulated at night-time, reaching borderline significance after adjustment for multiple comparisons (adjusted p = 0.058) ( Figure 6D ; Table S14 ).

also in 7,017 other papers

did not reach statistical significanceno p-value reported
Similar patterns in EGP to BL were also observed at FU, although the nighttime elevation in EGP at low-dose insulin did not reach statistical significance ( Figure 7G ).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.