Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype.

Analysis of the TCGA breast cancer database shows a highly significant correlation between CD163 or CD68 and SIGLEC9 but not with the epithelial markers, EPCAM or KRT8 (Fig.

also in 132,142 other papers

Encouragingly, SIGLEC9 expression showed a trend for an inverse correlation with MUC1-ST expression suggesting the down regulation of the receptor upon engagement (Supplementary Fig. 5d ), which was also observed at both the RNA and protein level in our in vitro studies (Supplementary Fig. 3f ).

also in 53,322 other papers