Algorithmic assessment of missense mutation severity in the Von-Hippel Lindau protein.

The p-value (p = .06) indicated that the algorithm scores for comparing the surface versus core-located mutations approached significance at the .05 α-value, suggesting that the observed trend towards a higher algorithm score (mean score = 13.2) in the surface mutations versus mutations occurring deeper in the VHL structure (mean score = 10.4) may have biological importance ( Fig 2D ).

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