Pan-cancer analysis of somatic mutations in miRNA genes.

It should be noted, however, that due to a low number of mutations, especially in the hotspots, the analysis is of relatively low statistical power, and most results are only nominally significant (Mann-Whitney or t-test, p<0.05; Supplementary Table S9), resulting in a relatively low number of miRNAs associated with the mutations in their genes.

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As shown in Supplementary Table S10 only mutations in groups of miRNA genes coding for miR-509-3p show borderline significant association with a decrease of the miRNA level.

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