Although there was a trend for a slight increase in growth retardation of irradiated LLC1 tumors grown on CD73-deficient background compared to WT mice, the differences in radiation-induced tumor growth delay between the LLC1 tumors grown in the C57BL/6 and CD73 −/− mice did not reach statistical significance ( Figures 2A,B ).
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Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue Toxicity.
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