Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence.

After iron depletion, Cyp46a1 transcript showed a statistical trend towards a 1.5-fold increase; it was not altered after iron overload.

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NRF2 encoding Nfe2l2 mRNA levels showed no regulation at all ( Figure 6 A), but its inhibitor Keap1 showed a trend towards reduction after 22BP, in good agreement with its protein levels in Figure 2 B and Supplementary Figure S2B .

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Pursuing the heme- and ISC-associated pathways into the cytosol, it is relevant that the putative heme release factor Pgrmc1 (Progesterone receptor membrane component 1), as a cytosolic factor in association with mitochondrial ferrochelatase, showed a highly significant and more than two-fold transcriptional induction after iron depletion.

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