Lipid Profile, Lipoprotein Subfractions, and Fluidity of Membranes in Children and Adolescents with Depressive Disorder: Effect of Omega-3 Fatty Acids in a Double-Blind Randomized Controlled Study.

Statistical analysis of HDL subfractions after supplementation with omega-3 and omega-6 FAs showed a significant difference in the level of L-HDL2 ( p = 0.011) subfraction and a marginally significant difference in L-HDL1 ( p = 0.084) and L-HDL3 ( p = 0.070) subfractions after 6 weeks of supplementation as well as S-HDL8 ( p =0.078) subfraction after 12 weeks of supplementation between the Om3 and Om6 groups ( Supplement Table S3 ).

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The correlation between CDI score and TCH in the stratified groups showed a trend towards a negative correlation in the group with TCH < 4.0 ( r = −0.216, p = 0.09) and a trend towards a positive correlation in the group with TCH > 4.0 ( r = 0.315, p = 0.076), whereas 44% of patients with MADD were in the group with TCH < 4.0 and 56% of patients with MADD in the group with TCH > 4.0. 3.2.

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Similarly, in our current work, supplementation with omega-3 FAs, but not omega-6 FAs, shifted the spectrum of HDL subfractions in depressed children in favor of large HDL subfractions (L-HDL1 to 3) after 6 and 12 weeks of supplementation and borderline significant reduced level of small HDL subfraction (S-HDL8) after 12 weeks of supplementation.

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The p -value was indicative of a borderline significance.

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