Assessment of a dose-response relationship In each of three studies that provided information on quartiles of sdLDL-C, there was a significant trend association found across quartiles, providing evidence of a dose-dependent relationship between sdLDL-C and risk of CHD ( Fig 4 ).
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Association of small, dense LDL-cholesterol concentration and lipoprotein particle characteristics with coronary heart disease: A systematic review and meta-analysis.
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