Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project.

The OR for risk of hypertension associated with the TT genotype remained similar whether the logistic regression analysis was performed in all participants up to 70 years, or split into those treated or not treated with antihypertensive drugs, albeit the relationship failed to reach statistical significance within either treated or untreated categories (owing to the loss of statistical power as a result of a 50% reduction in the sample size when split and considering that the variant TT genotype is represented by just 12% of the overall cohort).

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