Pipamperone Population Pharmacokinetics Related to Effectiveness and Side Effects in Children and Adolescents.

Clin Pharmacokinet · 2020 · PMC7658071 · PMID 32394297

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

a trend towards significancep = 0.07so close (0.05 < p ≤ 0.1)

The median [25th–75th percentile] predicted trough concentration for responders was higher than in non-responders: 80.0 μg/L [63.0–136.6] vs 51.3 μg/L [43.4–78.8], with a trend towards significance ( p = 0.07) (see Fig. 3 b).

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showed a trendno p-value reported

As the conversion of DBS concentrations to plasma concentrations based on the previously conducted clinical validation study [ 28 ] showed a trend towards under-estimation of the predicted concentrations by the model, a model-based conversion was calculated that showed better predictions.

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