a strong trendp = 0.0593
A statistically significant difference resulted for TRZ30 vs PLB at visit 4 (day 28) [95% CI − 1.57, − 0.15; p = 0.0182) and a strong trend was observed at visit 5 (day 35) [95% CI − 1.51, 0.03; p = 0.0593] and visit 9 (day 63) [95% CI − 1.41, 0.04; p = 0.0630] (Fig. 3 ).