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Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19.

Med Hypotheses · 2021 · PMC7659642 · PMID 33239231

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showed a trendno p-value reported
Remdesivir initially showed a trend in reducing the time to clinical improvement [11] .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.