Dual Effect of Soloxolone Methyl on LPS-Induced Inflammation In Vitro and In Vivo.

It should be emphasized that in this model of LPS-induced inflammation, the increase in the IL-6 level is robust ( Figure 8 B, LPS + vehicle), and SM administration to LPS-challenged mice additionally showed a trend toward increased IL-6 expression ( p = 0.04), while dexamethasone administration slightly but significantly ( p < 0.005) reduced the IL-6 level in the serum of experimental animals ( Figure 8 B).

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