Sulforaphane Promotes Dendritic Cell Stimulatory Capacity Through Modulation of Regulatory Molecules, JAK/STAT3- and MicroRNA-Signaling.

For mDCs, some differences for costimulatory molecules failed to achieve significance mainly due to the pronounced heterogeneity in the activation stage of each mDC donor, which is a well-known obstacle for the work with freshly isolated primary cells.

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Likewise, sulforaphane treatment of freshly isolated blood mDCs demonstrated a significant reduction of B7-H1 and a strong trend for downregulation of CD80 and CD83 regulatory molecules, although these differences did not achieve statistical significance ( Figure S1B ).

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