The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development?

Int J Mol Sci · 2020 · PMC7663510 · PMID 33153202

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may be significantno p-value reported

Demethylation of CpG islands in the CYP19A1 gene may be significant for the control of aromatase levels [ 139 ], although other explanations are possible as well, since 5-aza-deoxycytidine changes the expression levels of a broad spectrum of genes, which may either indirectly or directly affect aromatase expression.

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nominally significantno p-value reported

It is noteworthy that three variants within GREB1 area (close to rs13394619) and CDKN2B-AS1 (close to rs1537377) also demonstrated nominally significant relationships with endometriosis [ 33 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.