Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney.

While ACE was not within the top renal genes correlated with ACE2, it showed nominally significant positive association with ACE2 in both the discovery resource ( P = 0.0327) and TCGA ( P = 0.0032), consistent with previous studies. 27 Taken together, these data show that ACE2 is a highly abundant kidney gene with a cell-type-specific pattern of expression in the proximal tubule and functional overlap with metabolic processes of key relevance to human health and disease.

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