Significant decrease of von Willebrand factor and plasminogen activator inhibitor-1 by providing supplementation with selenium and coenzyme Q10 to an elderly population with a low selenium status.

After 10 years the numerical difference persisted, and a borderline significance was obtained regarding the difference between the two groups (CV+: 19.6 U/mL vs CV−: 9.4; p = 0.05).

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As the sample size in the present sub-study was small, the differences between the level of the biomarkers in those who suffered CV mortality after 5 and 10 years of follow-up, and the level in those without mortality did not reach statistical significance, even if the actual figures showed a similar difference.

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