Levels and Change in Galectin-3 and Association With Cardiovascular Events: The ARIC Study.

8 , 9 , 10 , 11 In the Framingham Offspring Study, log galectin‐3 was associated with incident HF in models adjusted for traditional risk factors and B‐type natriuretic peptide, but the association was attenuated and only marginally significant after adjustment for eGFR. 9 With longer follow‐up and more HF hospitalizations in ARIC, we extend previous observations by demonstrating that the association between midlife galectin‐3 and incident HF remained statistically significant after adjustment for eGFR and other biomarkers of HF risk (NT‐proBNP and hs‐TnT) and that galectin‐3 was associated with incident HF in both white and black individuals.

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