Despite demonstrating a slight reduction in RV fibrosis (13%) with sac/val treatment, this did not reach statistical significance (Figure 4 E and 4 F).
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Angiotensin Receptor-Neprilysin Inhibition Attenuates Right Ventricular Remodeling in Pulmonary Hypertension.
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The sentences
In the context of improved RV function and pressures, increased tissue density may indicate a combination of decreased collagen content (fibrosis) and/or recovery of inherent collagen fiber density, although we were able to detect only a nonsignificant trend in RV fibrosis in our histological measurements.