Epigenetic profiling of Italian patients identified methylation sites associated with hereditary transthyretin amyloidosis.

Nominally significant methylation differences were observed (i) between carriers vs. non-carriers at cg11481443 (standardized regression coefficient = −0.306, p = 3.4 × 10 –3 ; Additional file 6 : beta-value and M value plots) and cg02936398 (standardized regression coefficient = 0.177, p = 4.9 × 10 –2 ; Additional file 6 : beta-value and M value plots); (ii) hATTR patients and asymptomatic carriers at cg14311811 (standardized regression coefficient = −0.273, p = 3.8 × 10 –2 ; Additional file 6 : beta-value and M value plots).

also in 7,732 other papers