Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery.

Cancer Metastasis Rev · 2020 · PMC7680338 · PMID 32815102

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closest p

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quite significantno p-value reported

The P-loop is also quite significant from another perspective: 80% of all K-Ras oncogenic mutations occur in the Gly12 position of this segment [ 4 ], where the three major mutations are Gly12Cys, Gly12Asp, and Gly12Val (the occurrence is 16%, 40%, and 26% of all G12 mutations).

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