Elevated miR-124-3p in the aging colon disrupts mucus barrier and increases susceptibility to colitis by targeting T-synthase.

The mice pretreated with miR ‐ 124 ‐ 3p agomir showed a tendency to lose more bodyweight and exhibited an increased disease activity index (DAI) score (Figure 5a,b ), which was associated with shortening of the colon (Figure 5c,d , although it did not reach statistical significance), increased spleen weight (Figure 5e ), and more permeable fluorescein isothiocyanate (FITC)‐dextran (Figure 5f ), indicating worse injury.

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