SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease.

Nat Commun · 2020 · PMC7684291 · PMID 33230181

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0.0725

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0.0725

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showed a trendp = 0.0725so close (0.05 < p ≤ 0.1)

Whereas overexpression of sirt5 in wild-type animals did not lead to a significant change in OCR, Sirt5 significantly increased the OCR in sucla2 mutant zebrafish ( p = 0.0067) and showed a trend towards increased basal respiration ( p = 0.0725) (Fig. 5a–c ).

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