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A mouse model of human TLR4 D299G/T399I SNPs reveals mechanisms of altered LPS and pathogen responses.

J Exp Med · 2021 · PMC7685774 · PMID 33216117

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Reduced glycolytic capacity after low-dose LPS stimulation of the TLR4-SNP macrophages was also observed, although this trend did not reach statistical significance ( Fig.

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