Characterizing Exposure-Response Relationship for Therapeutic Monoclonal Antibodies in Immuno-Oncology and Beyond: Challenges, Perspectives, and Prospects.

Clin Pharmacol Ther · 2020 · PMC7689749 · PMID 32557643

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a negative trendno p-value reported

The E–R relationship for some safety end points with several therapeutic mAbs seems to have a negative trend, 10 , 11 , 12 , 39 but the mechanism is not well understood or explained.

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