Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Populations. Additional Analyses on Type-2 Diabetes Risk.

Consistently, the association of the MTNR1B-rs10830963 polymorphism with fasting glucose concentrations in the two replication cohorts (mean age over 65 years) did not reach statistical significance ( p > 0.05 for both).

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When only considering non-diabetic subjects in this cohort (OBENUTIC study), the association of the MTNR1B-rs10830963 polymorphism in the codominant ( p = 4 × 10 −6 ) as well as in the additive genetic model ( p = 6.84 × 10 −7 ) with fasting glucose concentrations in the model adjusted for sex, age, and obesity remained highly significant ( Figure 1 , panel B).

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