Prenatal Alcohol Exposure Results in Sex-Specific Alterations in Circular RNA Expression in the Developing Mouse Brain.

Front Neurosci · 2020 · PMC7693437 · PMID 33304235

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showed a trendno p-value reported

Furthermore, changes in S100 calcium-binding protein b ( S100b ), a gene enriched in astrocytes and radial glia, and brain-derived neurotrophic factor ( bdnf ; expressed in both neurons and glia) mRNA expression showed a trend for positive correlation with circPtchd2 , while circSatb2 exhibited a negative association with Bdnf levels in E18 whole brain ( Figures 5H,I,K,L ).

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an overall trendno p-value reported

Our results uncovered sex-specific changes in whole brain circRNA but not mRNA expression as a result of PAE, and demonstrated an overall trend for PAE to erase or reverse the sex dimorphic expression of the majority of circRNAs expressed at E18 whole brains.

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