High phosphate induces skeletal muscle atrophy and suppresses myogenic differentiation by increasing oxidative stress and activating Nrf2 signaling.

The serum Pi levels in CKD/NP mice (3.01 ± 0.20 mmol/L) were similar to those in sham/HP mice (2.94 ± 0.07 mmol/L) but, although raised in comparison to that of levels in sham/NP mice (2.75 ± 0.10 mmol/L) this difference did not reach statistical significance.

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