SGLT2 Inhibition by Intraperitoneal Dapagliflozin Mitigates Peritoneal Fibrosis and Ultrafiltration Failure in a Mouse Model of Chronic Peritoneal Exposure to High-Glucose Dialysate.

At the same time, dapagliflozin administered in the absence of a high-glucose milieu showed a trend toward PM thickening ( p = 0.10), whereas increases in proinflammatory cytokines such as IL-6, TNF-α, and MCP-1, and anti-inflammatory cytokines such as IL-10 and IFN-γ were not statistically significant.

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Again, similarly with profibrotic changes, there was a nonsignificant trend toward a high-glucose-independent increase in proinflammatory mediators MCP-1 and TNF-α in animals receiving saline and dapagliflozin ( Figure 5 B). 5.6.

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