However, the combination was more toxic than single-agent gemcitabine, since the frequency of grade ≥ 3 treatment-related adverse events was 69% with FOLFIRINOX and 60% with gemcitabine, even though this difference did not reach statistical significance ( p = 0.083).
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Statistical Considerations for Trials in Adjuvant Treatment of Colorectal Cancer.
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0.0830
0.0830