Contemporary epidemiology of rising atrial septal defect trends across USA 1991-2016: a combined ecological geospatiotemporal and causal inferential study.

eTable 2 quantitates these changes by linear regression and notes highly significant changes with time (β-estimate = 2.52, (95%C.I. 1.56, 3.48); with THC exposure index (β-estimate = 24.93, (1.06, 45.8)) and between the high and average ASD-rate states (Exposure: Status interaction (β-estimate = 10.72 (8.39–13.05), P < 2.2 × 10 − 16 ).

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Figure 2 b is a similar illustration of the relationship of ASD to various cannabinoids but here one notes a rising relationship with most cannabinoids with the notable exception of cannabidiol. eFigure 5 A displays the rate of cannabinoid exposure by year and notes that for cannabidiol this has been a negative trend which makes interpretation of its relationship with ASD complex (Fig. 2 b).

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