Reduced reticulum-mitochondria Ca²⁺ transfer is an early and reversible trigger of mitochondrial dysfunctions in diabetic cardiomyopathy.

4 f) revealed a reduced Ca 2+ transfer in HFHSD cardiomyocytes, becoming clearly significant at 2 Hz (Fig. 4 g), and confirmed by a significant decrease in the area under curve (SD: 67.3 [45.7, 88.7] vs HFHSD: 45.4 [26.8, 58.3] a.u, n = 26–34 cells from N = 3 mice/group, p < 0.05).

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