An earlier randomized clinical trial (RCT) comparing edoxaban and warfarin showed an unfavorable trend for low-dose edoxaban to prevent systemic embolism and stroke. 14 However, a recent published RCT for elderly Asian patients with AF favored low-dose edoxaban to prevent systemic embolism and stroke. 26 The optimal dose for Asian patients using edoxaban needs to be determined by further studies.
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Risk of recurrent stroke for Asian stroke patients treated with non-vitamin K antagonist oral anticoagulant and warfarin.
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