A trend for hyperglucagonemia was also observed for Bmal1 +/st DTA and Bmal1 st/st DTA mice treated with DOX at ZT4; however this tendency did not reach statistical significance ( Fig. 5 A, Bmal1 +/st DOX, Bmal1 st/st DOX).
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The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas.
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