Instability of Acylcarnitines in Stored Dried Blood Spots: The Impact on Retrospective Analysis of Biomarkers for Inborn Errors of Metabolism.

Int J Neonatal Screen · 2020 · PMC7712882 · PMID 33147805

Europe PMC DOI

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a significant trendno p-value reported

Only the C4/C8-, C8/C10-, and C14:1/C16-carnitine ratios did not demonstrate a significant trend upon long-term storage, as determined by Jonckheere’s trend test.

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a positive trendno p-value reported

The concentrations of C2-, C3-, C4-, C5-, C6-, C8-, C10:1-, C10-, C12:1-, C12-, C14:1-, C14-, C16:1-, C16-, C18:2-, C18:1-, C18-, C5OH+C4DC-, C18:1OH-, and C16DC-carnitine decreased significantly, whereas a positive trend was found for free carnitine.

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