Epithelial processed Mycobacterium avium subsp. paratuberculosis induced prolonged Th17 response and suppression of phagocytic maturation in bovine peripheral blood mononuclear cells.

The top 20 canonical pathways according to z-score (a score of the predicted direction of the pathway) showed a trend to overall suppression of corresponding pathways in both groups T1 and T2 at 72 h p.i., while “High mobility group box 1 (HMGB1) signaling” was found to be activated at 24 h p.i. and suppressed at 72 h p.i. in both groups (Fig. 2 B).

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