Stem cell and niche regulation in human short bowel syndrome.

Although LGR5 + cell populations were expanded, there was no change in WNT target gene expression, including cyclin D1 , C-MYC , DKK1 , or β-CATENIN , and AXIN2 expression showed a trend to be decreased in SBS compared with normal biopsies ( Figure 4A, P = 0.054).

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