A strong trend toward reduced counts of occludin/ZO-1 PLA spots was observed upon exposure to IFNγ+TNFα (−55% vs . control) or in co-treatment with 3-oxo-C12 (−46% vs . control).
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The intestinal quorum sensing 3-oxo-C12:2 Acyl homoserine lactone limits cytokine-induced tight junction disruption.
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