Remarkably, studying the H3K27ac signal within the overlapping peaks, we noticed that the regions losing methylation showed a trend towards higher H3K27ac levels, i.e., more activation, and those regions gaining methylation showed lower H3K27ac levels and, therefore, less active chromatin (Figure 2A-B).
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Chronic lymphocytic leukemias with trisomy 12 show a distinct DNA methylation profile linked to altered chromatin activation.
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