However, lixisenatide in the ELIXA trial [ 5 ] showed a trend for risk increase in MACE and the 2 drug classes in other cardiovascular outcome trials [ 6 – 12 ] showed a trend for risk reduction in MACE in this subgroup, with no statistical significance.
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Effects of glucagon-like peptide 1 receptor agonists and sodium glucose cotransporter 2 inhibitors on major adverse cardiovascular events in type 2 diabetes by race, ethnicity, and region: A meta-analysis.
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