Integrative genomic analysis implicates ERCC6 and its interaction with ERCC8 in susceptibility to breast cancer.

Haplotype analysis revealed borderline significant association of breast cancer with ERCC6 Hap 5 (OR 1.30, 95% CI 1.00–1.69, p = 0.048) (Supplementary Table 2 ).

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Although, the main effects of ERCC8 variations on breast cancer risk did not reach statistical significance in some of our GWAS datasets, we cannot rule out a main or modifying effect for ERCC8 given our findings of possible interaction between ERCC6 and ERCC8 in three of four GWAS analyzed.

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