Adjuvant Vaginal Use of Sildenafil Citrate in a Hormone Replacement Cycle Improved Live Birth Rates Among 10,069 Women During First Frozen Embryo Transfers.

12 To our knowledge, despite case reports, 12 , 18 , 19 there has been only one study of SC in FET cycles and one study in fresh ET cycles, both in thin-EM patients, and the results failed to reach statistical significance in differences in reproductive outcomes due to the limited sample sizes. 20 , 21 Therefore, large-scale clinical studies are urgently needed to validate the increasing empirical use of sildenafil in embryo transfer.

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