The observation of progressively higher DSG2 expression with higher cancer grade classification was notable, although the differences between grades 2 and 3 did not reach statistical significance, as the difference in PFS and general survival between DSG2-low and DSG2-high expressing populations, seen in two separate cohorts which lend further credence to the use of DSG2 expression levels as a prognostic indicator for ovarian cancer patients’ survival.
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