Barely Significant
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RSPO3 is a marker candidate for predicting tumor aggressiveness in ovarian cancer.

Ann Transl Med · 2020 · PMC7723610 · PMID 33313096

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a significant trendno p-value reported
We also reported a significant trend of decreased PFS and OS in ovarian cancer patients with a higher RSPO3 expression level, indicating that RSPO3 may serve as a novel prognostic factor in ovarian cancer.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.