Optimized OPA1 Isoforms 1 and 7 Provide Therapeutic Benefit in Models of Mitochondrial Dysfunction.

Front Neurosci · 2020 · PMC7726421 · PMID 33324145

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a clear trendno p-value reported

AAV2/2-OPA1 iso 1 (7.4 ± 3 μV) and AAV2/2-OPA1 iso 7 (3.9 ± 4.9 μV) treated animals show no statistical decrease in PhNR compared to untreated wt eyes (iso 1 cohort: 7.7 ± 4 μV, iso 7 cohort: 6.1 ± 4.1 μV), however there is a clear trend toward decreased PhNR in AAV2/2-OPA1 iso 7 treated eyes.

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did not quite reach significanceno p-value reported

Figure 5B shows there is a significant increase of total OPA1 protein in cells treated with OPA1 iso 1 virus, but this did not quite reach significance with OPA1 iso 7 treated cells.

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