Evading the host response: Staphylococcus "hiding" in cortical bone canalicular system causes increased bacterial burden.

Bulk allograft maintained a significantly higher infection intensity than cancellous allograft disc at the 1 × 10 2 inoculum on first peak POD 3 ( P < 0.001), second peak POD 35 ( P = 0.010), and approached significance at the conclusion of the experiment ( P = 0.07) (Fig. 2b and Supplementary Fig. 4 ).

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