Barely Significant
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Human Papillomavirus 16 (HPV16) E2 Repression of TWIST1 Transcription Is a Potential Mediator of HPV16 Cancer Outcomes.

mSphere · 2020 · PMC7729257 · PMID 33298572

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a significant trendno p-value reported
Not all E2-positive head and neck tumors have downregulation of TWIST1 compared with E2-negative tumors as evidenced by TCGA data, but there is a significant trend for downregulation.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.