Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners.

Nat Commun · 2020 · PMC7733462 · PMID 33311474

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did not reach statistical significanceno p-value reported

Q-PCR analysis of inflammatory gene expression in colon showed moderate downregulation of IL-1β, TNF-α, IL-6, Cxcl1, Cxcl2, and Ccl2 in Ripk K612R/K612R ; Ripk3 − / − mice compared with Ripk K612R/K612R mice but did not reach statistical significance (Supplementary Fig. 7g ).

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